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KMID : 0385219910010020151
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Korean Journal of Gerontology
1991 Volume.1 No. 2 p.151 ~ p.154
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Differential Changes in Levels of Metabolites and Enzymes in Mice Serum during the Administration of an Antimetabolite, 6-Aminonicotinamide
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Shin Sook
Kwon Young-Do
Lee Jae-Hyok
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Abstract
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The changes in enzymes and metabolites in mice serum were investigated at intervals of 3, 6, 9, 13 h, and 24 h after intraperitoneal administration of a single dose of 15㎎/㎏ of the antimetabolite 6-aminonicotinamide (6-AN). After administration of 6-AN, hyperglycemia reached its maximum at 13 h time period and amylase activity was enhances significantly. A significant decrease of protein concentration was observed after 6h of 6-AN treatment but glutamic oxaloacetate transaminase activity increased only slightly. The cholesterol level increased significantly after 6h of 6-AN administration and remained unchanged throughout later time intervals. The lipase activity increased significantly at 3, 6, 9h and 13h of 6-AN administration, followed by a rapid decline to near control values at later time intervals. Thus, it can be concluded that 6-AN produced a marked influence on levels of some biochemical metabolites such as glucose, protein and cholesterol as well as related enzymes in the serum of mice.
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KEYWORD
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6-aminonicotinamide, metabolites, enzymes, mice serum
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